Welcome to the Hu Lab
Dr. Hu’s lab aims to understand the pathogenesis of demyelination in peripheral nerve diseases. Demyelination is a common pathology in various peripheral neuropathies which collectively are highly prevalent. In contrast to axonal degeneration in peripheral neuropathies that are not responsive to treatments, demyelination often improves with treatments. Therefore, it is important to understand the underlying mechanisms leading to demyelination. Dr. Hu’s team is focused on the altered intercellular interactions among Schwann cells, axons, and macrophages in the demyelinating diseases, and how these molecular changes trigger segmental demyelination. The goal of Dr. Hu’s research is to identify key molecular targets that can be manipulated to halt or rescue the demyelination process.
![Bo-Hu](https://bo-hu.hmailabs.org/wp-content/uploads/2024/07/Bo-Hu-400x600.jpg)
Bo Hu, MD, PhD
Assistant Professor of Neurology, Academic institute
Assistant member, Research Institute
Stanley H. Appel Department of Neurology
Houston Methodist
Weill Cornell Medical College
Dr. Hu, a Neuroscientist, joined Houston Methodist in July 2022. He earned his M.D. and Ph.D. degrees from the University of South China. Dr. Hu completed his postdoctoral training under the mentorship of Dr. Jun Li at Vanderbilt University and was appointed as a Research Instructor at Vanderbilt University in 2017. He joined the Department of Neurology at Wayne State University to be an Assistant Professor in 2018 until his relocation to Houston Methodist in 2022. His research has been supported by the NIH funds.
Our Lab Focuses On
Inherited peripheral nerve diseases
Remyelination
Lysosomal storage
Demyelinating Diseases
Myelin lipid metabolism
Automated quantitative analysis of organelle morphology
Myelin biology
Nerve conduction study