Welcome to the Hu Lab

Dr. Hu’s lab aims to understand the pathogenesis of demyelination in peripheral nerve diseases. Demyelination is a common pathology in various peripheral neuropathies which collectively are highly prevalent. In contrast to axonal degeneration in peripheral neuropathies that are not responsive to treatments, demyelination often improves with treatments. Therefore, it is important to understand the underlying mechanisms leading to demyelination. Dr. Hu’s team is focused on the altered intercellular interactions among Schwann cells, axons, and macrophages in the demyelinating diseases, and how these molecular changes trigger segmental demyelination. The goal of Dr. Hu’s research is to identify key molecular targets that can be manipulated to halt or rescue the demyelination process.