Our research focuses on the following key areas:
- Understand the Alterations in Cellular Interactions during demyelination
Investigate how interactions among Schwann cells, axons, and macrophages are altered in demyelinating diseases, and how these alterations contribute to segmental demyelination. - Elucidate the Impact of Genetic Mutations
Identify and characterize the genetic mutations associated with demyelinating diseases and determine how these mutations affect molecular signaling among Schwann cells, axons, and macrophages. - Identify Key Molecular Targets
Utilize advanced molecular biology techniques to identify key proteins and signaling pathways that are dysregulated in demyelinating diseases.
Validate the functional relevance of these targets in disease pathogenesis using in vitro and in vivo models. - Develop Targeted Therapeutic Strategies
Design and test small molecules, antibodies, or gene therapies that can specifically modulate the identified molecular targets.
Assess the potential of these interventions to halt or reverse the demyelination process in preclinical models. - Clinical Translation
Collaborate with clinical teams to assess the safety and efficacy of the identified therapeutic agents in human clinical trials.